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Article

Bistable cell fate specification as a result of stochastic fluctuations and collective spatial cell behaviour.

PloS one - 28 Dec 2010

Stockholm Daniel, Edom-Vovard Frédérique, Coutant Sophie, Sanatine Peggy, Yamagata Yoshiaki, Corre Guillaume, Le Guillou Laurent, Neildez-Nguyen Thi My Anh, Pàldi Andràs

Abstract excerpt

BACKGROUND: In culture, isogenic mammalian cells typically display enduring phenotypic heterogeneity that arises from fluctuations of gene expression and other intracellular processes. This diversity is not just simple noise but has biological relevance by generating plasticity. Noise driven plasticity was suggested to be a stem cell-specific feature. RESULTS: Here we show that the phenotypes of proliferating...

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Identifiers

PMID: 21203432
DOI: 10.1371/journal.pone.0014441
PMCID: PMC3010982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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