Article

Cell fate-decision as high-dimensional critical state transition

2016-02-26

Abstract excerpt

Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage requires broad changes of their gene expression profile. However, how progenitor cells overcome the stability of their robust gene expression configuration (attractor) and exit their state remains elusive. Here we show that commitment of blood progenitor cells to the erythroid or the myeloid lineage is preceded by the desta...

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Literature Corpus work: 5fffa8b0-d019-580e-9d4f-d6fe5b389e78
DOI: 10.1101/041541

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