Article
Outer membrane proteins responsible for the penetration of beta-lactams and quinolones in Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy - 1 Aug 1990
Yamano Y, Nishikawa T, Komatsu Y
Abstract excerpt
Porin-deficient mutants of Pseudomonas aeruginosa PAO1 were selected by isolating latamoxef-resistant mutants following chemical mutagenesis. Highly latamoxef-resistant mutants had alterations in both the outer membrane proteins and penicillin-binding protein 3, a lethal target of latamoxef. Both...
Topics
- Anti-Bacterial Agents
- Anti-Infective Agents
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Carrier Proteins
- Cell Membrane Permeability
- Drug Resistance, Microbial
- Hexosyltransferases
- Humans
- Moxalactam
- Multienzyme Complexes
- Muramoylpentapeptide Carboxypeptidase
- Mutation
- Ofloxacin
- Penicillin-Binding Proteins
- Peptidyl Transferases
- Pseudomonas aeruginosa