Article
Outer membrane proteins responsible for the penetration of beta-lactams and quinolones in Pseudomonas aeruginosa.
The Journal of antimicrobial chemotherapy - 1 Aug 1990
Yamano Y, Nishikawa T, Komatsu Y
Abstract excerpt
Porin-deficient mutants of Pseudomonas aeruginosa PAO1 were selected by isolating latamoxef-resistant mutants following chemical mutagenesis. Highly latamoxef-resistant mutants had alterations in both the outer membrane proteins and penicillin-binding protein 3, a lethal target of latamoxef. Both of these alterations may be essential for cells to acquire high resistance to latamoxef. Many of the...
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