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Article

Structure-activity relationships of carbapenems that determine their dependence on porin protein D2 for activity against Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Feb 1995

Fung-Tomc J C, Huczko E, Banville J, Ménard M, Kolek B, Gradelski E, Kessler R E, Bonner D P

Abstract excerpt

A number of carbapenem derivatives were examined to determine the structure-activity relationships required for dependence on porin protein D2 for activity against Pseudomonas aeruginosa. As suggested by J. Trias and H. Nikaido (Antimicrob. Agents Chemother. 34:52-57, 1990), carbapenem derivatives, such as imipenem and meropenem, containing a sole basic group at position 2 of the molecule utilize the D2 channel...

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Identifiers

PMID: 7726504
DOI: 10.1128/AAC.39.2.394
PMCID: PMC162549

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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