Article
Structure-activity relationships of carbapenems that determine their dependence on porin protein D2 for activity against Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy - 1 Feb 1995
Fung-Tomc J C, Huczko E, Banville J, Ménard M, Kolek B, Gradelski E, Kessler R E, Bonner D P
Abstract excerpt
A number of carbapenem derivatives were examined to determine the structure-activity relationships required for dependence on porin protein D2 for activity against Pseudomonas aeruginosa. As suggested by J. Trias and H. Nikaido (Antimicrob. Agents Chemother. 34:52-57, 1990), carbapenem derivative...
Topics
- Bacterial Proteins
- Carbapenems
- Carrier Proteins
- Hexosyltransferases
- Lysine
- Meropenem
- Muramoylpentapeptide Carboxypeptidase
- Mutation
- Penicillin-Binding Proteins
- Peptidyl Transferases
- Porins
- Pseudomonas aeruginosa
- Structure-Activity Relationship
- Thienamycins