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Article

A novel assembly process of the multicomponent xenobiotic efflux pump in Pseudomonas aeruginosa.

Molecular microbiology - 1 Nov 2002

Maseda Hideaki, Kitao Masataka, Eda Shima, Yoshihara Eisaku, Nakae Taiji

Abstract excerpt

The nfxC-type cells of Pseudomonas aeruginosa show resistance to a wide range of structurally and functionally diverse antibiotics, which is a phenomenon that is mainly attributable to the expression of the MexEF-OprN xenobiotic transporter. The MexF, MexE and OprN subunits of this transporter are located on the inner membrane, the periplasm and the outer membrane, respectively, and are assumed to function as an...

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PMID: 12410825
DOI: 10.1046/j.1365-2958.2002.03197.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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Related research

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A novel assembly process of the multicomponent xenobiotic efflux pump in Pseudomonas aeruginosa.PMID 12410825Read ↗

Characterization of MexT, the regulator of the MexE-MexF-OprN multidrug efflux system of Pseudomonas aeruginosa.Semantic proximity Read ↗

Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa.Semantic proximity Read ↗

The role of mex-gene products in antibiotic extrusion in Pseudomonas aeruginosa.Semantic proximity Read ↗

Assembly of the MexAB-OprM multidrug efflux system of Pseudomonas aeruginosa: identification and characterization of mutations in mexA compromising MexA multimerization and interaction with MexB.Semantic proximity Read ↗

Constitutive Activation of MexT by Amino Acid Substitutions Results in MexEF-OprN Overproduction in Clinical Isolates of Pseudomonas aeruginosa.Semantic proximity Read ↗

Mutation of nfxB causes global changes in the physiology and metabolism of Pseudomonas aeruginosa.Semantic proximity Read ↗

Evidence of MexT-independent overexpression of MexEF-OprN multidrug efflux pump of Pseudomonas aeruginosa in presence of metabolic stress.Semantic proximity Read ↗

Amino Acid Substitutions Account for Most MexS Alterations in Clinical nfxC Mutants of Pseudomonas aeruginosa.Semantic proximity Read ↗

An elegant means of self-protection in gram-negative bacteria by recognizing and extruding xenobiotics from the periplasmic space.Semantic proximity Read ↗

Glnk Mediates Carbapenem Resistance Through the NtrB/NtrC-OprD Regulatory Pathway in Pseudomonas aeruginosa.Semantic proximity Read ↗

Variation of the mexT gene, a regulator of the MexEF-oprN efflux pump expression in wild-type strains of Pseudomonas aeruginosa.Semantic proximity Read ↗

Interplay between MexAB-OprM and MexEF-OprN in clinical isolates of Pseudomonas aeruginosaSemantic proximity Read ↗

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