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Article

The contribution of the exosite residues of plasminogen activator inhibitor-1 to proteinase inhibition.

The Journal of biological chemistry - 30 Jan 2004

Ibarra Catherine A, Blouse Grant E, Christian Thomas D, Shore Joseph D

Abstract excerpt

The binding of plasminogen activator inhibitor-1 (PAI-1) to serine proteinases, such as tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), is mediated by the exosite interactions between the surface-exposed variable region-1, or 37-loop, of the proteinase and the distal reactive center loop (RCL) of PAI-1. Although the contribution of such interactions to the inhibitory...

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PMID: 14594804
DOI: 10.1074/jbc.M310601200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The contribution of the exosite residues of plasminogen activator inhibitor-1 to proteinase inhibition.PMID 14594804Read ↗

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