Article
Melanocortin-1 receptor mutations and pigmentation: Insights from large animals.
Progress in molecular biology and translational science - 1 Jan 2022
Ji Ren-Lei, Tao Ya-Xiong
Abstract excerpt
The melanocortin-1 receptor (MC1R) is a G protein-coupled receptor expressed in cutaneous and hair follicle melanocytes, and plays a central role in coat color determination in vertebrates. Numerous MC1R variants have been identified in diverse species. Some of these variants have been associated with specific hair and skin color phenotypes in humans as well as coat color in animals. Gain-of-function mutations of...
Topics
- Animals
- Cattle
- Dogs
- Foxes
- Horses
- Mammals
- Mutation
- Phenotype
- Pigmentation
- Receptor, Melanocortin, Type 1
- Sheep
- Swine