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Article

APC/C<sup>Cdh1</sup>controls the proteasome-mediated degradation of E2F3 during cell cycle exit

15 May 2012

Abstract excerpt

E2F transcription factors regulate gene expression in concert with the retinoblastoma tumor suppressor family. These transcriptional complexes are master regulators of cell cycle progression and, in addition, control the expression of genes involved in DNA repair, G 2/M checkpoint and differentiation. E2F3 has recently attracted particular attention, because it is amplified in various human tumors. Here we show...

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PMID: 22580460
DOI: 10.4161/cc.20402

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