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Article

LPS induces greater bone and PDL loss in SPARC-null mice.

Journal of dental research - 1 Apr 2011

Trombetta-Esilva J, Yu H, Arias D N, Rossa C, Kirkwood K L, Bradshaw A D

Abstract excerpt

Individuals with periodontal disease have increased risk of tooth loss, particularly in cases with associated loss of alveolar bone and periodontal ligament (PDL). Current treatments do not predictably regenerate damaged PDL. Collagen I is the primary component of bone and PDL extracellular matrix. SPARC/Osteonectin (SP/ON) is implicated in the regulation of collagen content in healthy PDL. In this study,...

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Share to Aggregatibacter actinomycetemcomitans
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21191126
DOI: 10.1177/0022034510391800
PMCID: PMC3144132

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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