Article
Pseudomonas aeruginosa lipopolysaccharide induces osteoclastogenesis through a toll-like receptor 4 mediated pathway in vitro and in vivo.
The Laryngoscope - 1 May 2007
Zhuang Lei, Jung Jae Y, Wang Eric W, Houlihan Patrick, Ramos Lisette, Pashia Mary, Chole Richard A
Abstract excerpt
OBJECTIVES: Bacterial infections near bone result in localized inflammatory osteolysis, a significant complication of chronic ear infections. While many bacterial products may be involved, lipopolysaccharide (LPS) has been implicated as a major mediator of inflammation and osteolysis. However, the mechanisms by which LPS promotes bone resorption have not been clearly established. There is no consensus on whether...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.