Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dental and periodontal phenotype in sclerostin knockout mice.

International journal of oral science - 1 Jun 2014

Kuchler Ulrike, Schwarze Uwe Y, Dobsak Toni, Heimel Patrick, Bosshardt Dieter D, Kneissel Michaela, Gruber Reinhard

Abstract excerpt

Sclerostin is a Wnt signalling antagonist that controls bone metabolism. Sclerostin is expressed by osteocytes and cementocytes; however, its role in the formation of dental structures remains unclear. Here, we analysed the mandibles of sclerostin knockout mice to determine the influence of sclerostin on dental structures and dimensions using histomorphometry and micro-computed tomography (μCT) imaging. μCT and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Glycoproteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intercellular Signaling Peptides and Proteins

Share to Mice, Knockout

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 24699186
DOI: 10.1038/ijos.2014.12
PMCID: PMC5130054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dental and periodontal phenotype in sclerostin knockout mice.PMID 24699186Read ↗

Molecular Basis for Craniofacial Phenotypes Caused by Sclerostin Deletion.Semantic proximity Read ↗

Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model.Semantic proximity Read ↗

Sclerostin and DKK1 Inhibition Preserves and Augments Alveolar Bone Volume and Architecture in Rats with Alveolar Bone Loss.Semantic proximity Read ↗

Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength.Semantic proximity Read ↗

Sclerostin: Current Knowledge and Future PerspectivesSemantic proximity Read ↗

The Role of Sclerostin in Bone DiseasesSemantic proximity Read ↗

Anatomical similarity between the Sost-knockout mouse and sclerosteosis in humans.Semantic proximity Read ↗

The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary.Semantic proximity Read ↗

Localization of<i>SOST</i>/sclerostin in cementocytes<i>in vivo</i>and in mineralizing periodontal ligament cells<i>in vitro</i>Semantic proximity Read ↗

Sclerostin antibody enhances implant osseointegration in bone with Col1a1 mutation.Semantic proximity Read ↗

Mouse cellular cementum is highly dependent on growth hormone status.Semantic proximity Read ↗

Only minor differences in renal osteodystrophy features between wild-type and sclerostin knockout mice with chronic kidney disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.