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Article

p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells.

Clinical & experimental metastasis - 1 Jan 2007

Dong Peixin, Tada Mitsuhiro, Hamada Jun-Ichi, Nakamura Akihiro, Moriuchi Tetsuya, Sakuragi Noriaki

Abstract excerpt

Dominant negative (DN) mutations of tumor suppressor p53 (TP53) are clinically associated with cancer progression and metastasis of endometrial malignancy. To investigate the DN effect on tumor migration and invasion, we generated cells that stably co-expressed wild-type (wt) and R273H DN mutant...

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Source

Identifiers

PMID: 17636407
DOI: 10.1007/s10585-007-9084-8

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17636407-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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