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Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response

26 Jun 2013

Abstract excerpt

Tuberculosis associates with a wide spectrum of disease outcomes. The Beijing (Bj) lineage of Mycobacterium tuberculosis (Mtb) is suggested to be more virulent than other Mtb lineages and prone to elicit non-protective immune responses. However, highly heterogeneous immune responses were reported upon infection of innate immune cells with Bj strains or stimulation with their glycolipids. Using both in vitro and...

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PMID: 23840651
DOI: 10.1371/journal.pone.0067277

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