Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired neonatal survival of pro-opiomelanocortin null mutants.

Molecular and cellular endocrinology - 10 Apr 2011

Saedler Katarzyna, Hochgeschwender Ute

Abstract excerpt

Intercrosses of heterozygous pro-opiomelanocortin (POMC) mice result in homozygous null progeny at lower frequencies than expected. Genotyping offspring at pre-, peri-, and postnatal stages revealed that over half of homozygous null mutants die in the early postnatal stages. To investigate the reasons for this early postnatal lethality, we analyzed in detail different parameters in the initial hours after birth....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Mammalian
Share to Corticosterone
Share to Epinephrine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gluconeogenesis

Share to Glycogen

Share to Pro-Opiomelanocortin

Share to Pulmonary Surfactant-Associated Proteins

Share to Respiratory Function Tests

Source

Identifiers

PMID: 21184805
DOI: 10.1016/j.mce.2010.12.005

Genes

POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired neonatal survival of pro-opiomelanocortin null mutants.PMID 21184805Read ↗

Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin.Semantic proximity Read ↗

Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior.Semantic proximity Read ↗

Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adipositySemantic proximity Read ↗

Lack of proopiomelanocortin peptides results in obesity and defective adrenal function but normal melanocyte pigmentation in the murine C57BL/6 genetic background.Semantic proximity Read ↗

Corticosterone release is heightened in food or water deprived oxytocin deficient male mice.Semantic proximity Read ↗

A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene.Semantic proximity Read ↗

Aged PROP1 deficient dwarf mice maintain ACTH production.Semantic proximity Read ↗

Control of the hypothalamo-pituitary-adrenal axis in the neonatal period: adrenocorticotropin and corticosterone stress responses dissociate in vasopressin-deficient brattleboro rats.Semantic proximity Read ↗

Cyclic AMP response element-binding protein is required for normal maternal nurturing behavior.Semantic proximity Read ↗

Genetic modifications of mouse proopiomelanocortin peptide processing.Semantic proximity Read ↗

Low pup survival rate is associated with maternal Naq3 genotype and hypothalamic Vps8 expression levels in mice.Semantic proximity Read ↗

Null mutation of the prolactin receptor gene produces a defect in maternal behavior.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.