Null mutation of the prolactin receptor gene produces a defect in maternal behavior.

doi:10.1210/endo.139.10.6243

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Article

Null mutation of the prolactin receptor gene produces a defect in maternal behavior.

Endocrinology - 1 Oct 1998

Lucas B K, Ormandy C J, Binart N, Bridges R S, Kelly P A

Abstract excerpt

We have studied pup-directed maternal behavior in mice carrying a germ line null mutation of the PRL receptor (PRLR) gene. Homozygous mutant and heterozygous mutant nulliparous females show a deficiency in pup-induced maternal behavior. Moreover, primiparous heterozygous females exhibit a profoun...

Topics

Animals
Cognition
Female
Maternal Behavior
Maze Learning
Mice
Mutation
Pregnancy
Receptors, Prolactin
Smell
gamma-Aminobutyric Acid

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