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Article

Null mutation of the prolactin receptor gene produces a defect in maternal behavior.

Endocrinology - 1 Oct 1998

Lucas B K, Ormandy C J, Binart N, Bridges R S, Kelly P A

Abstract excerpt

We have studied pup-directed maternal behavior in mice carrying a germ line null mutation of the PRL receptor (PRLR) gene. Homozygous mutant and heterozygous mutant nulliparous females show a deficiency in pup-induced maternal behavior. Moreover, primiparous heterozygous females exhibit a profound deficit in maternal care when challenged with foster pups. Morris maze studies revealed normal configural learning in...

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Source

Identifiers

PMID: 9751488
DOI: 10.1210/endo.139.10.6243

Genes

PRLR
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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