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Article

A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene.

Human molecular genetics - 15 Dec 2010

Schaller Fabienne, Watrin Françoise, Sturny Rachel, Massacrier Annick, Szepetowski Pierre, Muscatelli Françoise

Abstract excerpt

The onset of feeding at birth is a vital step for the adaptation of the neonate to extra uterine life. Prader-Willi syndrome (PWS) is a complex neurogenetic disorder caused by the alteration of several imprinted contiguous genes including MAGEL2. PWS presents with various clinical manifestations, including poor suckling behaviour and feeding problems in neonates. Hypothalamic defects have been proposed, but the...

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Identifiers

PMID: 20876615
DOI: 10.1093/hmg/ddq424

Genes

MAGEL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A single postnatal injection of oxytocin rescues the lethal feeding behaviour in mouse newborns deficient for the imprinted Magel2 gene.PMID 20876615Read ↗

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A truncating mutation of <i>Magel2</i> in the rat modelled for the study of Schaaf-Yang and Prader-Willi syndromes alters select behavioral and physiological outcomesSemantic proximity Read ↗

Investigation of a Novel Mouse Model of Prader-Willi Syndrome with Invalidation of <i>Necdin</i> and <i>Magel2</i>Semantic proximity Read ↗

The Impact of Oxytocin on Neurite Outgrowth and Synaptic Proteins in <i>Magel2</i> -Deficient MiceSemantic proximity Read ↗

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