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Article

Lack of association between G-protein coupled receptor kinase 5 gene and Parkinson's disease.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2011

Tarantino Patrizia, De Marco Elvira Valeria, Annesi Grazia, Rocca Francesca Emanuela, Annesi Ferdinanda, Civitelli Donatella, Provenzano Giovanni, Scornaienchi Vittorio, Greco Valentina, Colica Carmela, Nicoletti Giuseppe, Quattrone Aldo

Abstract excerpt

The major component of Lewy Bodies (LB), the pathological hallmark of Parkinson's disease (PD) is α-synuclein, most prominently phosphorylated at serine 129. G-protein coupled receptor kinase 5 (GRK5) has been reported to phosphorylate α-synuclein in vitro, enhancing the α-synuclein toxicity to d...

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Identifiers

PMID: 21184589
DOI: 10.1002/ajmg.b.31129

Genes

GRK5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21184589-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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