Article

Lack of association between<i>G6PD</i>variants and Parkinson’s disease

2025-04-25

Abstract excerpt

Oxidative stress has been implicated in Parkinson’s disease (PD). Genes involved in PD, such as PRKN, PINK1 and PARK7 , contribute to oxidative stress in dopaminergic neurons. The X-linked G6PD gene encodes glucose 6-phosphate dehydrogenase, an important regulator of oxidative stress. Recent studies suggested that alpha-synuclein aggregates may impair G6PD activity and contribute to dopaminergic neuron loss, and t...

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Literature Corpus work: 2a16a3c6-1feb-5221-bb44-a98935b4ebe6
DOI: 10.1101/2025.04.23.25324774

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