Article
LINGO1 is not associated with Parkinson's disease in German patients.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2010
Klebe Stephan, Thier Sandra, Lorenz Delia, Nothnagel Michael, Schreiber Stefan, Klein Christine, Hagenah Johann, Kasten Meike, Berg Daniela, Srulijes Karin, Gasser Thomas, Deuschl Günther, Kuhlenbäumer Gregor
Abstract excerpt
Essential tremor (ET) and Parkinson's disease (PD) are the most common movement disorders and show clinical, genetic, and pathophysiological overlap. Single-nucleotide polymorphisms (SNPs) in the leucine-rich repeat (LRR) and immunoglobulin (Ig) domain-containing, Nogo receptor-interacting protein gene (LINGO1) are associated with ET. LINGO1 is overexpressed in the substantia nigra (SN) of PD patients and...
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