Article
No pathogenic mutations in the beta-synuclein gene in Parkinson's disease.
Neuroscience letters - 9 Jul 1999
Lincoln S, Crook R, Chartier-Harlin M C, Gwinn-Hardy K, Baker M, Mouroux V, Richard F, Becquet E, Amouyel P, Destée A, Hardy J, Farrer M
Abstract excerpt
We present 11 families consistent with autosomal dominant inheritance of probable Parkinson's disease (PD). Although excluded as a cause of disease in these kindreds, mutations in the alpha-synuclein gene have been implicated in familial PD. The beta-synuclein gene is highly homologous, expressed in the nervous system and thus is a good candidate gene for PD. Multipoint linkage analysis was either equivocal or...
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