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Article

Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011

Shaw Stanley Y, Blodgett David M, Ma Maggie S, Westly Elizabeth C, Clemons Paul A, Subramanian Aravind, Schreiber Stuart L

Abstract excerpt

Even as genetic studies identify alleles that influence human disease susceptibility, it remains challenging to understand their functional significance and how they contribute to disease phenotypes. Here, we describe an approach to translate discoveries from human genetics into functional and therapeutic hypotheses by relating human genetic variation to small-molecule sensitivities. We use small-molecule probes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21183721
DOI: 10.1073/pnas.1016789108
PMCID: PMC3021060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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