Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases.

doi:10.1038/s41588-023-01600-x

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Article

Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases.

Nature genetics - 1 Jan 2024

Homilius Max, Zhu Wandi, Eddy Samuel S, Thompson Patrick C, Zheng Huahua, Warren Caleb N, Evans Chiara G, Kim David D, Xuan Lucius L, Nsubuga Cissy, Strecker Zachary, Pettit Christopher J, Cho Jungwoo, Howie Mikayla N, Thaler Alexandra S, Wilson Evan, Wollison Bruce, Smith Courtney, Nascimben Julia B, Nascimben Diana N, Lunati Gabriella M, Folks Hassan C, Cupelo Matthew, Sridaran Suriya, Rheinstein Carolyn, McClennen Taylor, Goto Shinichi, Truslow James G, Vandenwijngaert Sara, MacRae Calum A, Deo Rahul C

Abstract excerpt

Although genome-wide association studies (GWAS) have successfully linked genetic risk loci to various disorders, identifying underlying cellular biological mechanisms remains challenging due to the complex nature of common diseases. We established a framework using human peripheral blood cells, physical, chemical and pharmacological perturbations, and flow cytometry-based functional readouts to reveal latent...

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Identifiers

PMID: 38049662
DOI: 10.1038/s41588-023-01600-x
PMCID: PMC10786715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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