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Exploring Sex Differences in Type 2 Diabetes via a Male-Dominant Beta-Cell Cluster from Single-Cell Pancreatic Sequencing of Public Datasets

19 May 2025

Abstract excerpt

BACKGRUOUND: Type 2 diabetes is a complex metabolic disorder characterized by insulin resistance and progressive beta-cell dysfunction. Although sex differences in type 2 diabetes prevalence, progression, and complications have been reported, the molecular mechanisms underlying these differences remain largely unknown. We aimed to utilize single-cell RNA sequencing to identify a beta-cell cluster that is more...

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Share to Genetic Associations and Epidemiology
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40389209
DOI: 10.3803/enm.2025.2297

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