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Article

Transcription termination maintains chromosome integrity.

Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011

Washburn Robert S, Gottesman Max E

Abstract excerpt

DNA replication fork movement is impeded by collisions with transcription elongation complexes (TEC). We propose that a critical function of transcription termination factors is to prevent TEC from blocking DNA replication and inducing replication fork arrest, one consequence of which is DNA double-strand breaks. We show that inhibition of Rho-dependent transcription termination by bicyclomycin in Escherichia...

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Identifiers

PMID: 21183718
DOI: 10.1073/pnas.1009564108
PMCID: PMC3021005

Genes

TEC

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