Article
Mutations in the essential Escherichia coli gene, yqgF, and their effects on transcription.
Journal of molecular microbiology and biotechnology - 1 Jan 2012
Iwamoto Akira, Osawa Atsushi, Kawai Makiko, Honda Hirofumi, Yoshida Saori, Furuya Nobuhisa, Kato Jun-Ichi
Abstract excerpt
The Escherichia coli yqgF gene is highly conserved across a broad spectrum of bacterial genomes. The gene was first identified as being essential for cell growth during screening for targets for broad-spectrum antibiotics. YqgF is structurally similar to RuvC, a Holliday junction resolvase, but its function has not been established. This study describes the isolation of a temperature-sensitive yqgF mutant, the...
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