Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

doi:10.1523/JNEUROSCI.4278-06.2007

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Article

Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Jun 2007

Zuccato Chiara, Belyaev Nikolai, Conforti Paola, Ooi Lezanne, Tartari Marzia, Papadimou Evangelia, MacDonald Marcy, Fossale Elisa, Zeitlin Scott, Buckley Noel, Cattaneo Elena

Abstract excerpt

Huntingtin is a protein that is mutated in Huntington's disease (HD), a dominant inherited neurodegenerative disorder. We previously proposed that, in addition to the gained toxic activity of the mutant protein, selective molecular dysfunctions in HD may represent the consequences of the loss of wild-type protein activity. We first reported that wild-type huntingtin positively affects the transcription of the...

Topics

Animals
Brain Chemistry
Brain-Derived Neurotrophic Factor
Cell Line, Transformed
Corpus Striatum
Down-Regulation
Gene Expression Regulation
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Huntingtin Protein

Huntington Disease

Immunoprecipitation

Mice

Mice, Knockout

Mice, Transgenic

Nerve Tissue Proteins

Neurons

Nuclear Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17596446
DOI: 10.1523/JNEUROSCI.4278-06.2007
PMCID: PMC6672230

Genes

BDNF
REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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