Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Presenilin controls CBP levels in the adult Drosophila central nervous system.

PloS one - 14 Dec 2010

Boyles Randy S, Lantz Kathryn M, Poertner Steven, Georges Stephanie J, Andres Andrew J

Abstract excerpt

BACKGROUND: Dominant mutations in both human Presenilin (Psn) genes have been correlated with the formation of amyloid plaques and development of familial early-onset Alzheimer's disease (AD). However, a definitive mechanism whereby plaque formation causes the pathology of familial and sporadic f...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Central Nervous System
Share to CREB-Binding Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crosses, Genetic

Share to Drosophila

Share to Gene Silencing

Share to Presenilins

Share to RNA Interference

Source

Open in PubMed Open full text

Identifiers

PMID: 21179466
DOI: 10.1371/journal.pone.0014332
PMCID: PMC3001863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21179466-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Presenilin controls CBP levels in the adult Drosophila central nervous system.PMID 21179466Read ↗

Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s DiseaseSemantic proximity Read ↗

Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein.Semantic proximity Read ↗

Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathwaysSemantic proximity Read ↗

Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathwaysSemantic proximity Read ↗

Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease.Semantic proximity Read ↗

An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila BrainSemantic proximity Read ↗

A reporter for amyloid precursor protein gamma-secretase activity in Drosophila.Semantic proximity Read ↗

Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.Semantic proximity Read ↗

Presenilins in the Developing, Adult, and Aging Cerebral CortexSemantic proximity Read ↗

Drosophila presenilin is required for neuronal differentiation and affects notch subcellular localization and signaling.Semantic proximity Read ↗

EPAC2 knockout causes abnormal tau pathology through calpain-mediated CDK5 activationSemantic proximity Read ↗

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.