Article
Presenilin controls CBP levels in the adult Drosophila central nervous system.
PloS one - 14 Dec 2010
Boyles Randy S, Lantz Kathryn M, Poertner Steven, Georges Stephanie J, Andres Andrew J
Abstract excerpt
BACKGROUND: Dominant mutations in both human Presenilin (Psn) genes have been correlated with the formation of amyloid plaques and development of familial early-onset Alzheimer's disease (AD). However, a definitive mechanism whereby plaque formation causes the pathology of familial and sporadic forms of AD has remained elusive. Recent discoveries of several substrates for Psn protease activity have sparked...
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