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Article

Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.

Proceedings of the National Academy of Sciences of the United States of America - 23 Aug 2005

Teo Jia-Ling, Ma Hong, Nguyen Cu, Lam Crystal, Kahn Michael

Abstract excerpt

Wnt/beta-catenin signaling has been shown to promote self-renewal in a variety of tissue stem cells, including neuronal stem cells and hematopoietic stem cells. However, activation of the Wnt/beta-catenin pathway promoted and inhibition of the pathway prevented differentiation of neuronal precurs...

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Source

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Identifiers

PMID: 16093313
DOI: 10.1073/pnas.0504600102
PMCID: PMC1189325

Genes

APP
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16093313-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation.PMID 16093313Read ↗

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