Article
Phenotypic analysis of Yersinia pseudotuberculosis 32777 response regulator mutants: new insights into two-component system regulon plasticity in bacteria.
International journal of medical microbiology : IJMM - 1 Apr 2008
Flamez Claire, Ricard Isabelle, Arafah Sonia, Simonet Michel, Marceau Michaël
Abstract excerpt
Two-component regulatory systems (2CSs) typically comprise a sensor kinase and a response regulator that, in concert, monitor the concentration of particular extracellular factors and mediate the transcription of specific genes accordingly. As such, 2CSs play an important role in the regulation of bacterial pathogenesis. On the basis of genome-wide in silico analysis, the Gram-negative enteropathogenic bacterium...
Topics
- Animals
- Bacterial Proteins
- Female
- Mice
- Mice, Inbred BALB C
- Mutation
- Phenotype
- Regulon
- Transcription Factors
- Virulence
- Yersinia pseudotuberculosis