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Article

Ancestral reconstruction of duplicated signaling proteins reveals the evolution of signaling specificity.

eLife - 10 Jun 2022

Nocedal Isabel, Laub Michael T

Abstract excerpt

Gene duplication is crucial to generating novel signaling pathways during evolution. However, it remains unclear how the redundant proteins produced by gene duplication ultimately acquire new interaction specificities to establish insulated paralogous signaling pathways. Here, we used ancestral sequence reconstruction to resurrect and characterize a bacterial two-component signaling system that duplicated in...

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Identifiers

PMID: 35686729
DOI: 10.7554/eLife.77346
PMCID: PMC9208753

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