A new carbon catabolite repression mutation of Escherichia coli, mlc∗, and its use for producing isobutanol.

Abstract excerpt

Sugar derived from biomass is usually a mixture of glucose and other sugars. When mixed sugars are fed to Escherichia coli, glucose is preferentially utilized while other sugars remain unutilized. This phenomenon is known as carbon catabolite repression (CCR). To utilize mixed sugars effectively, we isolated a new E. coli mutant that is negative for CCR. The mutant strain was revealed to have a nucleotide...

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