Article
High-Resolution Imaging of Human Cancer Proteins Using Microprocessor Materials.
Chembiochem : a European journal of chemical biology - 5 Sept 2022
Solares Maria J, Jonaid G M, Luqiu William Y, Berry Samantha, Khadela Janki, Liang Yanping, Evans Madison C, Pridham Kevin J, Dearnaley William J, Sheng Zhi, Kelly Deborah F
Abstract excerpt
Mutations in tumor suppressor genes, such as Tumor Protein 53 (TP53), are heavily implicated in aggressive cancers giving rise to gain- and loss-of-function phenotypes. While individual domains of the p53 protein have been studied extensively, structural information for full-length p53 remains incomplete. Functionalized microprocessor chips (microchips) with properties amenable to electron microscopy permitted us...
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