Article
Inhibition of VE-cadherin proteasomal degradation attenuates microvascular hyperpermeability.
Microcirculation (New York, N.Y. : 1994) - 1 Jan 2011
Sawant Devendra A, Tharakan Binu, Adekanbi Ashton, Hunter Felicia A, Smythe William Roy, Childs Ed W
Abstract excerpt
OBJECTIVE: VE-cadherin, an integral component of the adherens junction complex, is processed through the endosome-lysosome pathway and proteasome system for degradation. Our objective was to determine if inhibition of this pathway would protect against microvascular hyperpermeability. METHODS: To induce VE-cadherin degradation, we utilized a mutant VE-cadherin protein that lacks the extracellular domain (rVE-cad...
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