Article
Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos.
PloS one - 3 Jun 2009
Montero-Balaguer Mercedes, Swirsding Kendra, Orsenigo Fabrizio, Cotelli Franco, Mione Marina, Dejana Elisabetta
Abstract excerpt
BACKGROUND: VE-cadherin is an endothelial specific, transmembrane protein, that clusters at adherens junctions where it promotes homotypic cell-cell adhesion. VE-cadherin null mutation in the mouse results in early fetal lethality due to altered vascular development. However, the mechanism of action of VE-cadherin is complex and, in the mouse embryo, it is difficult to define the specific steps of vascular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.