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Ubiquitination of VE-cadherin regulates inflammation-induced vascular permeability in vivo

7 Aug 2024

Abstract excerpt

VE-cadherin is a major component of the cell adhesion machinery which provides integrity and plasticity of the barrier function of endothelial junctions. Here, we analyze whether ubiquitination of VE-cadherin is involved in the regulation of the endothelial barrier in inflammation in vivo. We show that histamine and thrombin stimulate ubiquitination of VE-cadherin in HUVEC, which is completely blocked if the two...

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PMID: 39112792
DOI: 10.1038/s44319-024-00221-7

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