Article

VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherin

2019-05-10

Abstract excerpt

Aberrant extra-vascular expression of VE-cadherin has been observed in metastasis associated with Vasculogenic Mimicry (VM); we have recently shown that in VM prone (VM+) tumor cells VE-cadherin is mainly in the form of pVE-cadherin in Y658 allowing an increased plasticity that potentiates VM development. As excessive VE-cadherin phosphorylation is regulated by the phosphatase VEPTP in endothelial cells in the cur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76713062-c879-5e9c-8e83-183892ca20df
DOI: 10.1101/634584

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

VE-PTP participates in vasculogenic mimicry by preventing autophagic degradation of VE-cadherinDOI 10.1101/634584Read

VE-Cadherin in Cancer-Associated Angiogenesis: A Deceptive Strategy of Blood Vessel FormationSemantic proximity Read

Primordial Vasculogenic Mimicry Formation in Uveal MelanomaSemantic proximity Read

Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicrySemantic proximity Read

Chromosomal 3p loss and 8q gain drive vasculogenic mimicry via HIF-2α and VE-cadherin activation in uveal melanomaSemantic proximity Read

Tyrosine phosphorylation of VE-cadherin prevents binding of p120- and beta-catenin and maintains the cellular mesenchymal state.Semantic proximity Read

Single tyrosine mutation in VE-cadherin modulates gene lung expressions: evidence for FOXF1 mediated S1PR1 upregulation to stabilize vessels in miceSemantic proximity Read

Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins.Semantic proximity Read

Inhibition of VE-cadherin proteasomal degradation attenuates microvascular hyperpermeability.Semantic proximity Read

Tumor-derived microvesicles induce proangiogenic phenotype in endothelial cells via endocytosis.Semantic proximity Read

VE-cadherin Y685F knock-in mouse is sensitive to vascular permeability in recurrent angiogenic organs.Semantic proximity Read

SOX7 blocks vasculogenic mimicry in oral squamous cell carcinomaSemantic proximity Read

p120-catenin regulates VE-cadherin endocytosis and degradation induced by the Kaposi sarcoma–associated ubiquitin ligase K5Semantic proximity Read