Sirt3 Maintains Microvascular Endothelial Adherens Junction Integrity to Alleviate Sepsis‐Induced Lung Inflammation by Modulating the Interaction of VE‐Cadherin and β‐Catenin

Abstract excerpt

Inflammatory injury is a hallmark of sepsis‐induced acute respiratory distress syndrome (ARDS)/acute lung injury (ALI). However, the mechanisms underlying inflammatory injury remain obscure. Here, we developed the novel strategy to suppress lung inflammation through maintaining microvascular endothelial barrier integrity. VE‐cadherin is the main adherens junction protein that interacts with β‐catenin and forms a...

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