Article
Cyclin D1 gene polymorphism and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population.
International journal of hematology - 1 Oct 2005
Hou Xuwei, Wang Sili, Zhou Yuling, Xu Ziliang, Zou Yao, Zhu Xiaofan, Han Mingzhe, Pang Tianxiang, Han Zhong Chao
Abstract excerpt
Cyclin D1 is a key protein involved in cell cycle regulation. A common A870G single nucleotide polymorphism in exon 4 of the cyclin D1 gene (CCND1) has an effect on the transcription of 2 different cyclin D1 messenger RNAs. Correlation between genetic polymorphism of A870G of CCND1 and clinical outcome among patients with acute lymphoblastic leukemia (ALL) has been reported. However, the effect on ALL occurrence...
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