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Article

Germline variants in MRE11/RAD50/NBN complex genes in childhood leukemia.

BMC cancer - 5 Oct 2013

Mosor Maria, Ziółkowska-Suchanek Iwona, Nowicka Karina, Dzikiewicz-Krawczyk Agnieszka, Januszkiewicz-Lewandowska Danuta, Nowak Jerzy

Abstract excerpt

BACKGROUND: The MRE11, RAD50, and NBN genes encode proteins of the MRE11-RAD50-NBN (MRN) complex involved in cellular response to DNA damage and the maintenance of genome stability. In our previous study we showed that the germline p.I171V mutation in NBN may be considered as a risk factor in the development of childhood acute lymphoblastic leukemia (ALL) and some specific haplotypes of that gene may be...

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Identifiers

PMID: 24093751
DOI: 10.1186/1471-2407-13-457
PMCID: PMC3851537

Genes

RAD50
MRE11
NBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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