Article

ATF4 regulates neuronal death in models of Parkinson’s Disease

2019-09-30

Abstract excerpt

Parkinson’s Disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra resulting in severe motor impairments. However, the mechanisms underlying this neuronal loss remain largely unknown. Activating Transcription Factor 4 (ATF4), a key mediator of the Integrated Stress Response (ISR), is a transcription factor that during prolonged activation can induce the expression of pro-apoptoti...

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Literature Corpus work: cf415e74-299f-5f24-b8a0-279d0b81ceed
DOI: 10.1101/783795

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