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Article

Intensive smoking diminishes the differences in quality of life and exacerbation frequency between the alpha-1-antitrypsin deficiency genotypes PiZZ and PiSZ.

Respiratory medicine - 1 Sept 2017

Bernhard Nikolas, Lepper Philipp M, Vogelmeier Claus, Seibert Martina, Wagenpfeil Stefan, Bals Robert, Fähndrich Sebastian

Abstract excerpt

BACKGROUND: Alpha-1-antitrypsin deficiency (AATD) is a rare genetic disorder that is associated with low levels of circulating alpha-1-antitrypsin in serum. In comparison to the genotype PiZZ, PiSZ usually leads to lower risk of emphysema, better lung function and better survival. The aim of this study was to analyze the relationship between cigarette smoking (packyears) and the AATD genotypes (PiZZ and PiSZ)...

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Identifiers

PMID: 29206626
DOI: 10.1016/j.rmed.2017.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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