Article
Stratification for smoking in case-cohort studies of genetic polymorphisms and lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Mar 2009
Sørensen Mette, López Ana García, Andersen Per Kragh, Vogel Ulla, Autrup Herman, Tjønneland Anne, Overvad Kim, Raaschou-Nielsen Ole
Abstract excerpt
The risk estimates obtained in studies of genetic polymorphisms and lung cancer differ markedly between studies, which might be due to chance or differences in study design, in particular the stratification/match of comparison group. The effect of different strategies for stratification and adjustment for smoking on the estimated effect of polymorphisms on lung cancer risk was explored in the case-cohort design....
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