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Article

Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases.

Human heredity - 1 Jan 2001

Silverman E K, Mosley J D, Rao D C, Palmer L J, Province M A, Elston R C, Weiss S T, Campbell E J

Abstract excerpt

OBJECTIVES: Severe alpha 1-antitrypsin (A1AT) deficiency is the one proven genetic risk factor for chronic obstructive pulmonary disease (COPD). Familial aggregation has been demonstrated for COPD among individuals who do not have A1AT deficiency, but linkage analysis of COPD has not been reported. To investigate the optimal phenotype definitions and analytical methods for the linkage analysis of COPD, we...

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Source

Identifiers

PMID: 11713419
DOI: 10.1159/000053380

Genes

FEV

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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