Article
Mutations within the hepatitis B virus genome among chronic hepatitis B patients with hepatocellular carcinoma.
Journal of medical virology - 1 Sept 2003
Bläckberg Jonas, Kidd-Ljunggren Karin
Abstract excerpt
Chronic hepatitis B infection is a major cause of hepatocellular cancer (HCC). The pathogenesis of the carcinogenesis is not fully understood. Viral proteins such as the X protein and the truncated middle S protein have been implicated to be transactivators. In order to investigate whether any mutations within relevant parts of the hepatitis B virus (HBV) genome could be associated with the development of HCC,...
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