Article
Association of the MAPT locus with Parkinson's disease.
European journal of neurology - 1 Mar 2010
Wider C, Vilariño-Güell C, Jasinska-Myga B, Heckman M G, Soto-Ortolaza A I, Cobb S A, Aasly J O, Gibson J M, Lynch T, Uitti R J, Wszolek Z K, Farrer M J, Ross O A
Abstract excerpt
BACKGROUND AND PURPOSE: Whilst an association between the tau gene (MAPT)-containing H1 haplotype and supranuclear gaze palsy (PSP) has long been recognized, the effect of H1 on risk for Parkinson's disease (PD) has remained more contentious. METHODS: Herein, we examined the association of H1 and PD in three Caucasian PD patient-control series from Ireland, Norway, and the US (combined: n = 2619), by genotyping...
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