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Article

Implications of OPRM1 and CYP2B6 variants on treatment outcomes in methadone-maintained patients in Ontario: Exploring sex differences.

PloS one - 1 Jan 2021

Chawar Caroul, Hillmer Alannah, Lamri Amel, Kapczinski Flavio, Thabane Lehana, Pare Guillaume, Samaan Zainab

Abstract excerpt

Genetic variants in the OPRM1 and CYP2B6 genes, respectively coding for an opioid receptor and methadone metabolizers, have been linked to negative treatment outcomes in patients undergoing methadone maintenance treatment, with little consensus on their effect. This study aims to test the associations between pre-selected SNPs of OPRM1 and CYP2B6 and outcomes of continued opioid use, relapse, and methadone dose....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34910759
DOI: 10.1371/journal.pone.0261201
PMCID: PMC8673616

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