Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Codeine-related deaths: The role of pharmacogenetics and drug interactions.

Forensic science international - 1 Jun 2014

Lam Jessica, Woodall Karen L, Solbeck Patricia, Ross Colin J D, Carleton Bruce C, Hayden Michael R, Koren Gideon, Madadi Parvaz

Abstract excerpt

The objective of this study was to assess the relationship between genetic polymorphisms and drug interactions on codeine and morphine concentrations in codeine-related deaths (CRD). All CRD in Ontario, Canada between 2006 and 2008 were identified. Post-mortem blood was analyzed for 22 polymorphisms in 5 genes involved in codeine metabolism and response. Sixty-eight CRD were included in this study. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Central Nervous System Depressants
Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Codeine

Share to Cytochrome P-450 CYP2D6 Inhibitors

Share to Drug Interactions

Share to Forensic Genetics

Share to Morphine

Share to Narcotics

Source

Identifiers

PMID: 24747667
DOI: 10.1016/j.forsciint.2014.03.018

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Codeine-related deaths: The role of pharmacogenetics and drug interactions.PMID 24747667Read ↗

Investigation of morphine and morphine glucuronide levels and cytochrome P450 isoenzyme 2D6 genotype in codeine-related deaths.Semantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update.Semantic proximity Read ↗

Post-mortem levels and tissue distribution of codeine, codeine-6-glucuronide, norcodeine, morphine and morphine glucuronides in a series of codeine-related deaths.Semantic proximity Read ↗

Prediction of Codeine Toxicity in Infants and Their Mothers Using a Novel Combination of Maternal Genetic MarkersSemantic proximity Read ↗

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for codeine therapy in the context of cytochrome P450 2D6 (CYP2D6) genotype.Semantic proximity Read ↗

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction between CYP2D6 and opioids (codeine, tramadol and oxycodone)Semantic proximity Read ↗

Life-threatening adverse events following therapeutic opioid administration in adults: is pharmacogenetic analysis useful?Semantic proximity Read ↗

Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother.Semantic proximity Read ↗

Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy.Semantic proximity Read ↗

Population Pharmacokinetic Quantification of CYP2D6 Activity in Codeine Metabolism in Ambulatory Surgical Patients for Model-Informed Precision Dosing.Semantic proximity Read ↗

CYP2D6 phenotype-specific codeine population pharmacokinetics.Semantic proximity Read ↗

CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.