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KCNMB1 genotype influences response to verapamil SR and adverse outcomes in the INternational VErapamil SR/Trandolapril STudy (INVEST).

Pharmacogenetics and genomics - 1 Sept 2007

Beitelshees Amber L, Gong Yan, Wang Danxin, Schork Nicholas J, Cooper-Dehoff Rhonda M, Langaee Taimour Y, Shriver Mark D, Sadee Wolfgang, Knot Harm J, Pepine Carl J, Johnson Julie A

Abstract excerpt

OBJECTIVES: We sought to determine whether polymorphisms in the large-conductance calcium and voltage-dependent potassium (BK) channel beta1 subunit gene, KCNMB1, are associated with blood pressure response to verapamil SR or adverse outcomes in the GENEtic substudy of the INternational VErapamil SR/trandolapril STudy (INVEST-GENES). BACKGROUND: KCNMB1 is involved in calcium sensitivity and hypertension. The...

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Identifiers

PMID: 17700361
DOI: 10.1097/FPC.0b013e32810f2e3c
PMCID: PMC2713584

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