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Article

Gene dosage effects in chronic lymphocytic leukemia.

Cancer genetics and cytogenetics - 1 Dec 2010

Sellmann Ludger, Scholtysik Rene, Kreuz Markus, Cyrull Sandra, Tiacci Enrico, Stanelle Jens, Carpinteiro Alexander, Nückel Holger, Boes Tanja, Gesk Stefan, Siebert Reiner, Klein-Hitpass Ludger, Dührsen Ulrich, Dürig Jan, Küppers Ralf

Abstract excerpt

To understand the influence of chromosomal alterations on gene expression in a genome-wide view, chromosomal imbalances detected by single nucleotide polymorphism (SNP) chips were compared with global gene expression in 16 cases of chronic lymphocytic leukemia (CLL). A strong concordance between chromosomal gain or loss and increased or reduced expression of genes in the affected regions was found, respectively....

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Source

Identifiers

PMID: 21156227
DOI: 10.1016/j.cancergencyto.2010.09.002

Genes

BCL2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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