Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.

doi:10.1371/journal.pgen.1003373

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Article

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.

PLoS genetics - 1 Apr 2013

Garding Angela, Bhattacharya Nupur, Claus Rainer, Ruppel Melanie, Tschuch Cordula, Filarsky Katharina, Idler Irina, Zucknick Manuela, Caudron-Herger Maïwen, Oakes Christopher, Fleig Verena, Keklikoglou Ioanna, Allegra Danilo, Serra Leticia, Thakurela Sudhir, Tiwari Vijay, Weichenhan Dieter, Benner Axel, Radlwimmer Bernhard, Zentgraf Hanswalter, Wiemann Stefan, Rippe Karsten, Plass Christoph, Döhner Hartmut, Lichter Peter, Stilgenbauer Stephan, Mertens Daniel

Abstract excerpt

Non-coding RNAs are much more common than previously thought. However, for the vast majority of non-coding RNAs, the cellular function remains enigmatic. The two long non-coding RNA (lncRNA) genes DLEU1 and DLEU2 map to a critical region at chromosomal band 13q14.3 that is recurrently deleted in solid tumors and hematopoietic malignancies like chronic lymphocytic leukemia (CLL). While no point mutations have been...

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PMID: 23593011
DOI: 10.1371/journal.pgen.1003373
PMCID: PMC3616974

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